ea0037ep515 | Diabetes (complications & therapy) | ECE2015
Neff Karl
, Elliott Jessie
, Jackson Sabrina
, Abegg Kathrin
, Corteville Caroline
, Munoz Rodrigo
, Docherty Neil
, Lutz Thomas
, le Roux Carel
Background: The effect of Roux-en-Y gastric bypass (RYGB) on diabetic kidney disease (DKD) is unclear. We used a Zucker diabetic fatty rat (ZDF) model of DKD to determine the effect of RYGB on histopathological markers of DKD, proteinuria, and MCP1 excretion.Methods: ZDF rats underwent RYGB (n=15) or sham surgery (n=14) at 18 weeks of age. Eight sham operated animals were food restricted to match the weight loss of the RYGB group (body-...